c-Rel antibody (N-Term)

Catalog No. ABIN2774658

The Rabbit Polyclonal anti-c-Rel antibody has been validated for WB. It is suitable to detect c-Rel in samples from Human, Mouse, Rat, Dog, Horse, Cow, Rabbit, Guinea Pig and Zebrafish (Danio rerio).

Quick Overview for c-Rel antibody (N-Term) (ABIN2774658)

Target: c-Rel (REL proto-oncogene (c-Rel))

Reactivity: Human, Mouse, Rat, Dog, Horse, Cow, Rabbit, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-Rel antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-c-Rel Antibody

Binding Specificity: N-Term

Sequence: ASGAYNPYIE IIEQPRQRGM RFRYKCEGRS AGSIPGEHST DNNRTYPSIQ

Cross-Reactivity: Chicken, Human, Mouse (Murine)

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 92%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against REL. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human REL

Application Details

Application Notes: WB Suggested Anti-REL Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:312500
Positive Control: Hela cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 619 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for c-Rel

Target: c-Rel (REL proto-oncogene (c-Rel))

Alternative Name: REL

Background: REL is a member of the Rel/NFKB family, which also includes RELA, RELB, NFKB1, and NFKB2. These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor.The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed 18037997]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-174 CN414487.1 2-175 175-2323 X75042.1 128-2276 2324-2457 BX111941.1 575-708 2458-2592 AA279919.1 1-135 c
Alias Symbols: C-Rel
Protein Interaction Partner: NFKB2, REXO1L6P, C12orf75, TRIM74, RAB41, BARHL2, SEC14L4, NUDT14, ZDHHC24, NEIL2, CPNE2, C9orf72, STRA13, TTC21A, FUT11, ZNF564, ZNF550, PATE1, TSTD2, ZNF417, ZNF572, GLYCTK, EGLN3, RIPPLY1, ZNF765, ATPAF2, SLC39A13, BMF, KRTAP9-4, CEP19, VPS25, MIEN1, P
Protein Size: 619

Molecular Weight: 68 kDa

Gene ID: 5966

NCBI Accession: NM_002908, NP_002899

UniProt: Q04864