FBXO21 antibody (N-Term)

Catalog No. ABIN2774725

This Rabbit Polyclonal antibody specifically detects FBXO21 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Dog, Rabbit, Guinea Pig, Cow and Saccharomyces cerevisiae.

Quick Overview for FBXO21 antibody (N-Term) (ABIN2774725)

Target: FBXO21 (F-Box Protein 21 (FBXO21))

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Guinea Pig, Cow, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXO21 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-FBXO21 Antibody

Binding Specificity: N-Term

Sequence: KEQFRVRWPS LMKHYSPTDY VNWLEEYKVR QKAGLEARKI VASFSKRFFS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%

Characteristics: This is a rabbit polyclonal antibody against FBXO21. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FBXO21

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 621 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for FBXO21

Target: FBXO21 (F-Box Protein 21 (FBXO21))

Alternative Name: FBXO21

Background: FBXO21 contains 1 F-box domain. It is a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.
Alias Symbols: DKFZp434G058, FBX21, FLJ90233, KIAA0875, MGC26682
Protein Interaction Partner: TP53, CDKN1A, SUMO1, SMURF1, NEDD8, UBC, COPS5, COPS6, CUL1, ELAVL1, CNTNAP4, TERF2, TERF1,
Protein Size: 621

Molecular Weight: 71 kDa

Gene ID: 23014

NCBI Accession: NM_015002, NP_055817

UniProt: O94952