SYVN1 antibody (Middle Region)

Catalog No. ABIN2774800

The Rabbit Polyclonal anti-SYVN1 antibody has been validated for WB. It is suitable to detect SYVN1 in samples from Human, Mouse, Rat, Horse, Dog, Cow, Guinea Pig, Rabbit and Saccharomyces cerevisiae.

Quick Overview for SYVN1 antibody (Middle Region) (ABIN2774800)

Target: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Reactivity: Human, Mouse, Rat, Horse, Dog, Cow, Guinea Pig, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYVN1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SYVN1 Antibody

Binding Specificity: Middle Region

Sequence: QGLLPPFPPG MFPLWPPMGP FPPVPPPPSS GEAVAPPSTS AALSRPSGAA

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%

Characteristics: This is a rabbit polyclonal antibody against SYVN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SYVN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 616 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SYVN1

Target: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Alternative Name: SYVN1

Background: SYVN1 is a protein involved in endoplasmic reticulum (ER)-associated degradation. The protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins.This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. This gene and the mitochondrial ribosomal protein L49 gene use in their respective 3' UTRs some of the same genomic sequence. Sequence analysis identified two transcript variants that encode different isoforms.
Alias Symbols: HRD1, KIAA1810, MGC40372
Protein Interaction Partner: Rer1, OS9, SEL1L, STXBP5L, UBC, SYVN1, DERL2, HEY2, HEY1, USP19, Ube2g2, MARCH6, VCP, YOD1, ATXN3, DERL1, HERPUD1, TP53, BSG, ASGR1, GPR37, UBE2D3, UBE2D2, USP7, ATN1, APOB, ERLEC1, UBXN8, SHH, ERN1, ASGR2, SARAF, FAM8A1, TYR, AUP1, ERLIN2, SGK1, ATP6AP1,
Protein Size: 616

Molecular Weight: 67 kDa

Gene ID: 84447

NCBI Accession: NM_032431, NP_115807

UniProt: Q86TM6

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling