STUB1 antibody (C-Term)

Catalog No. ABIN2774917

This Rabbit Polyclonal antibody specifically detects STUB1 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Guinea Pig, Dog, Horse and Zebrafish (Danio rerio).

Quick Overview for STUB1 antibody (C-Term) (ABIN2774917)

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Dog, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STUB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-STUB1 Antibody

Binding Specificity: C-Term

Sequence: VDEKRKKRDI PDYLCGKISF ELMREPCITP SGITYDRKDI EEHLQRVGHF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against STUB1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human STUB1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 303 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for STUB1

Target: STUB1 (STIP1 Homology and U-Box Containing Protein 1 (STUB1))

Alternative Name: STUB1

Background: STUB1 modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. It has E3 ubiquitin-protein ligase activity and targets misfolded chaperone substrates towards proteasomal degradation. STUB1 mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.
Alias Symbols: CHIP, HSPABP2, NY-CO-7, SDCCAG7, UBOX1
Protein Interaction Partner: HSP90AA1, HSPA8, PCSK9, OLFM3, ATCAY, CCL28, UBE2Q1, TXN2, RUSC1, HSPA1B, FMR1, ERN1, STUB1, UBE2V1, UBE2N, UBE2D3, UBE2D1, UBC, TP53, MAPT, MAP3K11, SNAI2, BAG1, HSPA4L, CDC37, DNAJB6, BAG2, BAG3, BAG4, MLF2, HSP90AB1, HSPA4, HSPA2, HSPA1L, ENDOG, TXLNG,
Protein Size: 303

Molecular Weight: 35 kDa

Gene ID: 10273

NCBI Accession: NM_005861, NP_005852

UniProt: Q9UNE7

Pathways: Regulation of Hormone Metabolic Process, Response to Water Deprivation