DC-SIGN/CD209 antibody (N-Term)

Catalog No. ABIN2775487

This Rabbit Polyclonal antibody specifically detects DC-SIGN/CD209 in WB. It exhibits reactivity toward Human and Pig.

Quick Overview for DC-SIGN/CD209 antibody (N-Term) (ABIN2775487)

Target: DC-SIGN/CD209 (CD209) (CD209)

Reactivity: Human, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DC-SIGN/CD209 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DC-SIGN/CD209 Antibody

Binding Specificity: N-Term

Sequence: AGCLGHGPLV LQLLSFTLLA GLLVQVSKVP SSISQEQSRQ DAIYQNLTQL

Predicted Reactivity: Human: 100%, Pig: 86%

Characteristics: This is a rabbit polyclonal antibody against CD209. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CD209

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 404 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DC-SIGN/CD209

Target: DC-SIGN/CD209 (CD209) (CD209)

Alternative Name: CD209

Background: This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332, often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
Alias Symbols: CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, MGC129965
Protein Interaction Partner: VAC14, IKBKE, LSP1, CYLD, LGALS3BP, CEACAM5, CLU, CLEC4M, CD209, ICAM3, ICAM2, ITGAM, CEACAM1, SP1, HCVgp1,
Protein Size: 404

Molecular Weight: 46 kDa

Gene ID: 30835

NCBI Accession: NM_021155, NP_066978

UniProt: Q9NNX6