DNASE2B antibody (Middle Region)

Catalog No. ABIN2775492

The Rabbit Polyclonal anti-DNASE2B antibody has been validated for WB. It is suitable to detect DNASE2B in samples from Human, Guinea Pig, Cow, Horse, Rat and Pig.

Quick Overview for DNASE2B antibody (Middle Region) (ABIN2775492)

Target: DNASE2B (Deoxyribonuclease II beta (DNASE2B))

Reactivity: Human, Guinea Pig, Cow, Horse, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNASE2B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DNASE2B Antibody

Binding Specificity: Middle Region

Sequence: IKAIKLSRHS YFSSYQDHAK WCISQKGTKN RWTCIGDLNR SPHQAFRSGG

Predicted Reactivity: Cow: 93%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Pig: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against DNASE2B. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DNASE2B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 357 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DNASE2B

Target: DNASE2B (Deoxyribonuclease II beta (DNASE2B))

Alternative Name: DNASE2B

Background: DNASE2B shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH . Unlike DNase II which is ubiquitously expressed, expression of this protein is restricted to the salivary gland and lungs. The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH . Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: DLAD
Protein Interaction Partner: UBC, UBD,
Protein Size: 357

Molecular Weight: 39 kDa

Gene ID: 58511

NCBI Accession: NM_021233, NP_067056

UniProt: Q8WZ79