Symplekin antibody (N-Term)

Catalog No. ABIN2775623

The Rabbit Polyclonal anti-Symplekin antibody has been validated for WB and IHC. It is suitable to detect Symplekin in samples from Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig and Horse.

Quick Overview for Symplekin antibody (N-Term) (ABIN2775623)

Target: Symplekin (SYMPK)

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Symplekin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Symplekin Antibody

Binding Specificity: N-Term

Sequence: RTHAIKFVEG LIVTLSPRMA DSEIPRRQEH DISLDRIPRD HPYIQYNVLW

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SYMPK. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SYMPK

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1274 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Symplekin

Target: Symplekin (SYMPK)

Alternative Name: SYMPK

Background: SYMPK is a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ27092, SPK, SYM
Protein Interaction Partner: KAT6A, VCP, KMT2A, UBC, WWOX, RPA3, RPA2, RPA1, SSU72, CPSF2, CPSF3, TOP1, SUMO1, SIRT7, SUMO2, SMARCAD1, CSTF2, HTT, HSF1,
Protein Size: 1274

Molecular Weight: 141 kDa

Gene ID: 8189

NCBI Accession: NM_004819, NP_004810

UniProt: Q92797