UBE2D2 antibody (Middle Region)

Catalog No. ABIN2775673

This anti-UBE2D2 antibody is a Rabbit Polyclonal antibody detecting UBE2D2 in WB and IHC. Suitable for Human, Mouse, Rat, Cow, Dog, Rabbit, Zebrafish (Danio rerio), Horse and Guinea Pig. This Primary Antibody has been cited in 1 publication.

Quick Overview for UBE2D2 antibody (Middle Region) (ABIN2775673)

Target: UBE2D2 (Ubiquitin-Conjugating Enzyme E2D 2 (UBE2D2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Zebrafish (Danio rerio), Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2D2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-UBE2D2 Antibody

Binding Specificity: Middle Region

Sequence: SQWSPALTIS KVLLSICSLL CDPNPDDPLV PEIARIYKTD REKYNRIARE

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against UBE2D2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human UBE2D2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 547 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-UBE2D2 antibody (ABIN2775673)

Desforges, Lacey, Glazier, Greenwood, Mynett, Speake, Sibley: "SNAT4 isoform of system A amino acid transporter is expressed in human placenta." in: American journal of physiology. Cell physiology, Vol. 290, Issue 1, pp. C305-12, (2005) (PubMed).

Target Details for UBE2D2

Target: UBE2D2 (Ubiquitin-Conjugating Enzyme E2D 2 (UBE2D2))

Alternative Name: UBE2D2

Background: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2D2 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase.SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral amino acids is Na(+) and pH dependent (Hatanaka et al., 2001).[supplied by OMIM].
Alias Symbols: E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH5B
Protein Interaction Partner: RNF26, CHFR, RBX1, DZIP3, UBA1, UBC, TRAF6, BIRC7, anapc11, ZNRF1, RNF146, MID1, MDM2, BIRC3, FZR1, ITCH, HRD1, CUL3, XIAP, MARCH7, RNF25, UBE2D2, RNF130, UBA6, CBLC, PARK2, TRIM21, KCMF1, RNF135, MUL1, MDM4, TRIM23, STUB1, CBL, UBTD1, RNF38, UBI4, RFFL,
Protein Size: 547

Molecular Weight: 60 kDa

Gene ID: 7322

NCBI Accession: NM_018018, NP_003330

UniProt: P62837

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades