SMARCAL1 antibody (N-Term)

Catalog No. ABIN2775719

The Rabbit Polyclonal anti-SMARCAL1 antibody is suitable to detect SMARCAL1 in samples from Human, Mouse, Rat, Cow, Horse, Dog, Rabbit, Guinea Pig, Pig and Saccharomyces cerevisiae. It has been validated for WB.

Quick Overview for SMARCAL1 antibody (N-Term) (ABIN2775719)

Target: SMARCAL1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1))

Reactivity: Human, Mouse, Rat, Cow, Horse, Dog, Rabbit, Guinea Pig, Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMARCAL1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMARCAL1 Antibody

Binding Specificity: N-Term

Sequence: MSLPLTEEQR KKIEENRQKA LARRAEKLLA EQHQRTSSGT SIAGNPFQAK

Predicted Reactivity: Cow: 79%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 83%

Characteristics: This is a rabbit polyclonal antibody against SMARCAL1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SMARCAL1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 954 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMARCAL1

Target: SMARCAL1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A-Like 1 (SMARCAL1))

Alternative Name: SMARCAL1

Background: SMARCAL1 is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Mutations in SMARCAL1 gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency. The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphyseal dysplasia, renal dysfunction, and T-cell immunodeficiency.
Alias Symbols: HARP, HHARP
Protein Interaction Partner: UBC, RPA3, RPA2, RPA1, SULT1A1, Cebpb,
Protein Size: 954

Molecular Weight: 106 kDa

Gene ID: 50485

NCBI Accession: NM_014140, NP_054859

UniProt: Q9NZC9

Pathways: Embryonic Body Morphogenesis