TRPC4 antibody (Middle Region)

Catalog No. ABIN2776213

The Rabbit Polyclonal anti-TRPC4 antibody (ABIN2776213) specifically detects TRPC4 in WB and IHC. The antibody is reactive with Human, Rat, Mouse, Cow, Dog, Pig, Guinea Pig, Horse and Rabbit samples.

Quick Overview for TRPC4 antibody (Middle Region) (ABIN2776213)

Target: TRPC4 (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4))

Reactivity: Human, Rat, Mouse, Cow, Dog, Pig, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPC4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TRPC4 Antibody

Binding Specificity: Middle Region

Sequence: CPFKSEKVVV EDTVPIIPKE KHAKEEDSSI DYDLNLPDTV THEDYVTTRL

Predicted Reactivity: Cow: 86%, Dog: 93%, Guinea Pig: 82%, Horse: 77%, Human: 100%, Mouse: 100%, Pig: 85%, Rabbit: 100%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against TRPC4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TRPC4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 977 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRPC4

Target: TRPC4 (Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4))

Alternative Name: TRPC4

Background: TRPC4 is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC4 probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. It has also been shown to be calcium-selective. TRPC4 may also be activated by intracellular calcium store depletion.
Alias Symbols: HTRP4, MGC119570, MGC119571, MGC119572, MGC119573, TRP4, HTRP-4
Protein Interaction Partner: UBC, TRPC4AP, TNFRSF1A, TRPC1, ITCH, SLC9A3R1, TJP1, ITPR2, TRPC5, ITPR3, ITPR1, MX1, TRPC4, TRPC6, TRPC3, HOMER3,
Protein Size: 977

Molecular Weight: 112 kDa

Gene ID: 7223

NCBI Accession: NM_016179, NP_057263

UniProt: Q9UBN4