CELF6 antibody (Middle Region)

Catalog No. ABIN2776609

This anti-CELF6 antibody is a Rabbit Polyclonal antibody detecting CELF6 in WB. Suitable for Human, Mouse, Rat, Cow, Guinea Pig and Rabbit.

Quick Overview for CELF6 antibody (Middle Region) (ABIN2776609)

Target: CELF6 (CUGBP, Elav-Like Family Member 6 (CELF6))

Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CELF6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CELF6 Antibody

Binding Specificity: Middle Region

Sequence: QAALLAAAQG PGLGPVAAVA AQMQHVAAFS LVAAPLLPAA AANSPPGSGP

Predicted Reactivity: Cow: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against BRUNOL6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human BRUNOL6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 481 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for CELF6

Target: CELF6 (CUGBP, Elav-Like Family Member 6 (CELF6))

Alternative Name: BRUNOL6

Background: BRUNOL6 is a RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. It mediates exon inclusion and/or exclusion in pre-mRNAs that are subject to tissue-specific and developmentally regulated alternative splicing. BRUNOL6 specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. It also promotes exon exclusion of INSR pre-mRNA.Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation.
Alias Symbols: CELF6, BRUNOL6
Protein Size: 481

Molecular Weight: 50 kDa

Gene ID: 60677

NCBI Accession: NM_052840, NP_443072

UniProt: Q96J87