FBLN3 antibody (Middle Region)

Catalog No. ABIN2776756

The Rabbit Polyclonal anti-FBLN3 antibody has been validated for WB. It is suitable to detect FBLN3 in samples from Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse, Pig and Zebrafish (Danio rerio). There is 1 publication available.

Quick Overview for FBLN3 antibody (Middle Region) (ABIN2776756)

Target: FBLN3 (Fibulin 3 (FBLN3))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse, Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBLN3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FBLN3 Antibody

Binding Specificity: Middle Region

Sequence: KYMSIRSDRS VPSDIFQIQA TTIYANTINT FRIKSGNENG EFYLRQTSPV

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against EFEMP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human EFEMP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 493 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FBLN3 antibody (ABIN2776756)

Lutter, Xie, Tatin, Makinen: "Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation." in: The Journal of cell biology, Vol. 197, Issue 6, pp. 837-49, (2012) (PubMed).

Target Details for FBLN3

Target: FBLN3 (Fibulin 3 (FBLN3))

Alternative Name: EFEMP1

Background: EFEMP1 gene spans approximately 18 kb of genomic DNA and consists of 12 exons. Alternative splice patterns in the 5' UTR result in three transcript variants encoding the same extracellular matrix protein. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy.This gene spans approximately 18 kb of genomic DNA and consists of 12 exons. Alternative splice patterns in the 5' UTR result in three transcript variants encoding the same extracellular matrix protein. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy.
Alias Symbols: DHRD, DRAD, FBLN3, FBNL, FLJ35535, MGC111353, MLVT, MTLV, S1-5
Protein Interaction Partner: TXNDC5, RIC8A, BAG6, TRAF2, SGTA, env, HCVgp1, KHDRBS1, TNIP1, SOCS6, UBC, PDIA3, NOS3, GFI1B, ATN1, RERE, ATXN7, CACNA1A, ARAF, TIMP3, RAF1,
Protein Size: 493

Molecular Weight: 53 kDa

Gene ID: 2202

NCBI Accession: NM_004105, NP_004096

UniProt: Q12805

Pathways: EGFR Signaling Pathway