DDC antibody (N-Term)

Catalog No. ABIN2776802

The Rabbit Polyclonal anti-DDC antibody has been validated for WB and IHC. It is suitable to detect DDC in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Horse and Zebrafish (Danio rerio). There is 1 publication available.

Quick Overview for DDC antibody (N-Term) (ABIN2776802)

Target: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-DDC Antibody

Binding Specificity: N-Term

Sequence: EFRRRGKEMV DYVANYMEGI EGRQVYPDVE PGYLRPLIPA AAPQEPDTFE

Predicted Reactivity: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 92%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against DDC. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DDC

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 480 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-DDC antibody (ABIN2776802)

Shimohata, Ishihara, Hattori, Miyamoto, Morishita, Ornthanalai, Raveau, Ebrahim, Amano, Yamada, Sago, Akiba, Mataga, Murphy, Miyakawa, Yamakawa: "Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism." in: Experimental neurology, Vol. 293, pp. 1-12, (2017) (PubMed).

Target Details for DDC

Target: DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase) (DDC))

Alternative Name: DDC

Background: DDC catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Alias Symbols: AADC
Protein Interaction Partner: ATF6, RELA, AR,
Protein Size: 480

Molecular Weight: 53 kDa

Gene ID: 1644

NCBI Accession: NM_000790, NP_000781

UniProt: P20711

Pathways: Dopaminergic Neurogenesis