DPYS antibody (N-Term)

Catalog No. ABIN2776832

The Rabbit Polyclonal anti-DPYS antibody has been validated for WB. It is suitable to detect DPYS in samples from Human, Mouse, Rat, Cow, Dog, Rabbit, Zebrafish (Danio rerio), Guinea Pig and Pig. There are 2+ publications available.

Quick Overview for DPYS antibody (N-Term) (ABIN2776832)

Target: DPYS (Dihydropyrimidinase (DPYS))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Zebrafish (Danio rerio), Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DPYS antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DPYS Antibody

Binding Specificity: N-Term

Sequence: VLDAAGKLVL PGGIDTHTHM QFPFMGSRSI DDFHQGTKAA LSGGTTMIID

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against DPYS. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DPYS

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 519 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-DPYS antibody (ABIN2776832)

Thomas, Chen, Lin, Tomlinson, Lam, Liu, Yeung, Chan, Wong: "Middle cerebral artery stenosis increased the risk of vascular disease mortality among type 2 diabetic patients." in: Cerebrovascular diseases (Basel, Switzerland), Vol. 25, Issue 3, pp. 261-7, (2008) (PubMed).

Thomas, Ezzeldin, Guarcello, Mattison, Fridley, Diasio: "Genetic regulation of beta-ureidopropionase and its possible implication in altered uracil catabolism." in: Pharmacogenetics and genomics, Vol. 18, Issue 1, pp. 25-35, (2008) (PubMed).

Target Details for DPYS

Target: DPYS (Dihydropyrimidinase (DPYS))

Alternative Name: DPYS

Background: Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.
Alias Symbols: DHP, DHPase
Protein Interaction Partner: DPYSL5,
Protein Size: 519

Molecular Weight: 56 kDa

Gene ID: 1807

NCBI Accession: NM_001385, NP_001376

UniProt: Q14117