Vitamin D Receptor antibody (N-Term)

Catalog No. ABIN2776857

This anti-Vitamin D Receptor antibody is a Rabbit Polyclonal antibody detecting Vitamin D Receptor in WB. Suitable for Human.

Quick Overview for Vitamin D Receptor antibody (N-Term) (ABIN2776857)

Target: Vitamin D Receptor (VDR)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Vitamin D Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Vitamin D Receptor Antibody

Binding Specificity: N-Term

Sequence: EAMAASTSLP DPGDFDRNVP RICGVCGDRA TGFHFNAMTC EGCKGFFRRS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against VDR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human VDR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 427 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Vitamin D Receptor

Target: Vitamin D Receptor (VDR)

Alternative Name: VDR

Target Type: Chemical

Background: The nuclear hormone receptor for vitamin D3 also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: NR1I1
Protein Interaction Partner: MED12, MED24, BAZ1B, SMARCA4, RXRA, MED1, NCOA2, NSD1, NCOA1, SRPK1, PTPN3, Hr, NKD2, MMRN2, CDCA7L, CXXC5, UBC, RXRB, PRKCSH, PRCP, CFH, CCND3, MYC, MXD1, BRCA1, PSMC5, NCOR1, SRC, NCOA6, PPP1CC, CDK11B, NR1H2, RXRG, CASC4, GABARAPL1, GABARAPL2, CLASRP,
Protein Size: 427

Molecular Weight: 48 kDa

Gene ID: 7421

NCBI Accession: NM_000376, NP_000367

UniProt: P11473

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway