TGM1 antibody (N-Term)

Catalog No. ABIN2776952

The Rabbit Polyclonal anti-TGM1 antibody has been validated for WB. It is suitable to detect TGM1 in samples from Human, Mouse, Rat, Dog, Rabbit, Guinea Pig, Horse and Cow.

Quick Overview for TGM1 antibody (N-Term) (ABIN2776952)

Target: TGM1 (Transglutaminase 1, Keratinocyte (TGM1))

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Guinea Pig, Horse, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGM1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TGM1 Antibody

Binding Specificity: N-Term

Sequence: RGSSSGTRRP GSRGSDSRRP VSRGSGVNAA GDGTIREGML VVNGVDLLSS

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TGM1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TGM1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 817 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TGM1

Target: TGM1 (Transglutaminase 1, Keratinocyte (TGM1))

Alternative Name: TGM1

Background: TGM1 is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE).The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ICR2, KTG, LI, LI1, TGASE, TGK
Protein Interaction Partner: BMI1, SNCA, UBC, Ttk, HSPB1, RARRES3, SEMG2, SEMG1, MDK,
Protein Size: 817

Molecular Weight: 90 kDa

Gene ID: 7051

NCBI Accession: NM_000359, NP_000350

UniProt: P22735