TSH receptor antibody (C-Term)

Catalog No. ABIN2777037

This Rabbit Polyclonal antibody specifically detects TSH receptor in WB. It exhibits reactivity toward Human, Mouse, Rat, Dog, Rabbit, Sheep, Cow, Horse and Guinea Pigand has been mentioned in 1 publication.

Quick Overview for TSH receptor antibody (C-Term) (ABIN2777037)

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Reactivity: Human, Mouse, Rat, Dog, Rabbit, Sheep, Cow, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSH receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TSH receptor Antibody

Binding Specificity: C-Term

Sequence: KLDAVYLNKN KYLTVIDKDA FGGVYSGPSL LLPLGRKSLS FETQKAPRSS

Predicted Reactivity: Cow: 83%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 93%, Sheep: 79%

Characteristics: This is a rabbit polyclonal antibody against TSHR. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TSHR

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 253 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TSH receptor antibody (ABIN2777037)

Pessina, Castillo, Sartore, Borrego, Meikle: "Semiquantitative immunohistochemical marker staining and localization in canine thyroid carcinoma and normal thyroid gland." in: Veterinary and comparative oncology, (2014) (PubMed).

Target Details for TSH receptor

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Alternative Name: TSHR

Background: TSHR is receptor for thyrothropin. It plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. It also acts as a receptor for thyrostimulin (GPA2+GPB5).
Alias Symbols: LGR3, MGC75129, hTSHR-I, CHNG1
Protein Interaction Partner: ADRB2, SCRIB, UBC, TSHB, RABAC1, GNA13, GNA12, FLNB, TSHR, GNAQ, PIK3R1, LHCGR, JAK2, JAK1, GNAI3, GNAI2, GNAS, GNA11, GNAO1, GNAI1, HSPA5, FN1, CANX, CALR, STAT3, CALCR,
Protein Size: 253

Molecular Weight: 28 kDa

Gene ID: 7253

NCBI Accession: NM_001018036, NP_001018046

UniProt: Q96GT6

Pathways: Thyroid Hormone Synthesis