Chromogranin A antibody (N-Term)

Catalog No. ABIN2777070

The Rabbit Polyclonal anti-Chromogranin A antibody has been validated for WB. It is suitable to detect Chromogranin A in samples from Human, Rat, Mouse, Pig, Cow, Horse and Dog.

Quick Overview for Chromogranin A antibody (N-Term) (ABIN2777070)

Target: Chromogranin A (CHGA)

Reactivity: Human, Rat, Mouse, Pig, Cow, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Chromogranin A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Chromogranin A Antibody

Binding Specificity: N-Term

Sequence: PVSQECFETL RGDERILSIL RHQNLLKELQ DLALQGAKER AHQQKKHSGF

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against CHGA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CHGA

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 457 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Chromogranin A

Target: Chromogranin A (CHGA)

Alternative Name: CHGA

Background: CHGA is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. Its gene?s product is a precursor to three biologically active peptides, vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides, vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown.
Alias Symbols: CGA
Protein Interaction Partner: PARK2, UBC, CDC37, PFDN1, NEK2, SCG3, PLG,
Protein Size: 457

Molecular Weight: 51 kDa

Gene ID: 1113

NCBI Accession: NM_001275, NP_001266

UniProt: P10645

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling