FOSL1 antibody (Middle Region)

Catalog No. ABIN2777265

The Rabbit Polyclonal anti-FOSL1 antibody has been validated for WB and IHC. It is suitable to detect FOSL1 in samples from Human, Rat, Mouse, Dog, Cow, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio) and Sheep. There are 2+ publications available.

Quick Overview for FOSL1 antibody (Middle Region) (ABIN2777265)

Target: FOSL1 (FOS-Like Antigen 1 (FOSL1))

Reactivity: Human, Rat, Mouse, Dog, Cow, Rabbit, Guinea Pig, Horse, Zebrafish (Danio rerio), Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOSL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-FOSL1 Antibody

Binding Specificity: Middle Region

Sequence: TDFLQAETDK LEDEKSGLQR EIEELQKQKE RLELVLEAHR PICKIPEGAK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 85%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against FOSL1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human FOSL1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 271 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-FOSL1 antibody (ABIN2777265)

Seitz, Schürmann, Pfeilschifter, Frank, Sader: "Identification of the Fra-1 transcription factor in healing skin flaps transplants: a potential role as a negative regulator of VEGF release from keratinocytes." in: Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, Vol. 40, Issue 4, pp. 379-86, (2012) (PubMed).

Kashiwada, Cassel, Colgan, Rothman: "NFIL3/E4BP4 controls type 2 T helper cell cytokine expression." in: The EMBO journal, Vol. 30, Issue 10, pp. 2071-82, (2011) (PubMed).

Target Details for FOSL1

Target: FOSL1 (FOS-Like Antigen 1 (FOSL1))

Alternative Name: FOSL1

Background: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. The FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
Alias Symbols: FRA1, fra-1, FRA
Protein Interaction Partner: NME7, CREB5, USF1, LDOC1, JUNB, MAFB, MAF, JUN, DDIT3, ATF2, CEBPG, CEBPE, CEBPA, ATF4, ATF3, PARVG, WFDC1, TAB2, ATXN1, MYC, KPNA1, PSMC3, EP300, CREBBP, TRIM24, UBC, HDAC1, CALCOCO1, ATF1, CREB1, SRF, ELK1,
Protein Size: 271

Molecular Weight: 29 kDa

Gene ID: 8061

NCBI Accession: NM_005438, NP_005429

UniProt: P15407