HDAC6 antibody (N-Term)

Catalog No. ABIN2777306

This Rabbit Polyclonal antibody specifically detects HDAC6 in WB, IHC and ChIP. It exhibits reactivity toward Human, Mouse, Rat, Pig, Rabbit, Dog, Guinea Pig, Cow and Horse.

Quick Overview for HDAC6 antibody (N-Term) (ABIN2777306)

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Reactivity: Human, Mouse, Rat, Pig, Rabbit, Dog, Guinea Pig, Cow, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

Product Details anti-HDAC6 Antibody

Binding Specificity: N-Term

Sequence: VGLQGMDLNL EAEALAGTGL VLDEQLNEFH CLWDDSFPEG PERLHAIKEQ

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against HDAC6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HDAC6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 1215 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HDAC6

Target: HDAC6 (Histone Deacetylase 6 (HDAC6))

Alternative Name: HDAC6

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
Alias Symbols: HD6, JM21
Protein Interaction Partner: HSP90B1, ACTB, UBC, TRIM50, MYH10, DYNC1H1, DDIT3, ELAVL1, MAPK3, MAPK1, RUNX2, TUBA1B, SUMO1, RANBP9, NEDD8, ADRB2, ATXN3, MEF2B, SQSTM1, HSP90AA1, RASSF2, SLMAP, SAV1, CTTNBP2NL, BAG3, SETD8, TUBB, HSPA8, HSPA6, HSPA5, HSPA4, HSPA2, HSPA1L, DNAJA1, ETV6
Protein Size: 1215

Molecular Weight: 131 kDa, 17 kDa

Gene ID: 10013

NCBI Accession: NM_006044

UniProt: Q9UBN7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling