SCMH1 antibody (Middle Region)

Catalog No. ABIN2777417

This Rabbit Polyclonal antibody specifically detects SCMH1 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Horse, Rabbit and Saccharomyces cerevisiae.

Quick Overview for SCMH1 antibody (Middle Region) (ABIN2777417)

Target: SCMH1 (Sex Comb On Midleg Homolog 1 (SCMH1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCMH1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SCMH1 Antibody

Binding Specificity: Middle Region

Sequence: LTGDNLQPPG TKVVIPKNPY PASDVNTEKP SIHSSTKTVL EHQPGQRGRK

Predicted Reactivity: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 86%, Yeast: 79%

Characteristics: This is a rabbit polyclonal antibody against SCMH1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SCMH1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 591 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SCMH1

Target: SCMH1 (Sex Comb On Midleg Homolog 1 (SCMH1))

Alternative Name: SCMH1

Background: SCMH1 is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Alias Symbols: Scml3
Protein Interaction Partner: UBQLN1, RNF2, MAGEA12, BMI1, UBQLN4, PHC3, CBX4, PCGF2, PHC2, PHC1, MAML3, LZTR1, PCBD1, EWSR1, TMEM11, SCMH1, MOB4, TOB1, POLR2M, LYPLA2, GMNN, HK1, Cbx2,
Protein Size: 591

Molecular Weight: 65 kDa

Gene ID: 22955

NCBI Accession: NM_012236, NP_036368