TOLLIP antibody (C-Term)

Catalog No. ABIN2777431

This Rabbit Polyclonal antibody specifically detects TOLLIP in WB. It exhibits reactivity toward Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Guinea Pig, Horse, Rabbit and Saccharomyces cerevisiaeand has been mentioned in 1 publication.

Quick Overview for TOLLIP antibody (C-Term) (ABIN2777431)

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Guinea Pig, Horse, Rabbit, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOLLIP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TOLLIP Antibody

Binding Specificity: C-Term

Sequence: MATTVSTQRG PVYIGELPQD FLRITPTQQQ RQVQLDAQAA QQLQYGGAVG

Predicted Reactivity: Cow: 85%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 83%, Rat: 100%, Yeast: 79%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against TOLLIP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TOLLIP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 274 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TOLLIP antibody (ABIN2777431)

Schimming, Parwez, Petrasch-Parwez, Nothnagel, Epplen, Hoffjan: "Association of toll-interacting protein gene polymorphisms with atopic dermatitis." in: BMC dermatology, Vol. 7, pp. 3, (2007) (PubMed).

Target Details for TOLLIP

Target: TOLLIP (Toll Interacting Protein (TOLLIP))

Alternative Name: TOLLIP

Background: TOLLIP is component of the signaling pathway of IL-1 and Toll-like receptors. It Inhibits cell activation by microbial products. It also recruits IRAK1 to the IL-1 receptor complex and inhibits IRAK1 phosphorylation and kinase activity.
Alias Symbols: FLJ33531, IL-1RAcPIP
Protein Interaction Partner: RBPMS, TOM1, DAZAP2, UBC, SIAH1, PRR20A, WDYHV1, CPSF6, DAB1, ATG8, MAP1LC3A, SQSTM1, NBR1, VPS35, OXR1, VPS29, CYHR1, NMI, APEH, RHOXF2, TOM1L1, IRAK1, PINK1, INTS4P2, SNX8, TRIP6, UBD, TGFBR1, ATXN1, SMAD7, TOM1L2, TOLLIP, GGA1, GGA3, GGA2, TRAF6, RAC1,
Protein Size: 274

Molecular Weight: 30 kDa

Gene ID: 54472

NCBI Accession: NM_019009, NP_061882

UniProt: Q9H0E2