TDP2 antibody (Middle Region)

Catalog No. ABIN2777707

There is 1 publication for this product available. The Rabbit Polyclonal anti-TDP2 antibody is suitable to detect TDP2 in samples from Human, Mouse, Rat, Rabbit, Cow, Dog, Horse and Guinea Pig. It has been validated for WB and IHC.

Quick Overview for TDP2 antibody (Middle Region) (ABIN2777707)

Target: TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TDP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TDP2 Antibody

Binding Specificity: Middle Region

Sequence: IPPYYSYLKK RSSNYEIITG HEEGYFTAIM LKKSRVKLKS QEIIPFPSTK

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TTRAP. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TTRAP

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 362 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-TDP2 antibody (ABIN2777707)

Xu, Pan, Wang, Huang, Tian, Xue, Chen, Jia: "TTRAP is a novel PML nuclear bodies-associated protein." in: Biochemical and biophysical research communications, Vol. 375, Issue 3, pp. 395-8, (2008) (PubMed).

Target Details for TDP2

Target: TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))

Alternative Name: TTRAP

Background: The TTRAP gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.
Alias Symbols: TDP2, EAP2, AD022, EAPII, TTRAP, dJ30M3.3, RP1-30M3.3
Protein Interaction Partner: UBC, SRPK2, SUMO1, SUMO2, SUMO3, TAP1, SKIL, ATXN1, PSEN1, SMAD3, EPS8, DLX3, ATP5G2, C2orf88, JAM2, SNX13, AKAP9, RAB11A, PARK7, MAPK6, UBE2I, TRAF5, TRAF6, TRAF3, TRAF2, FLI1, TNFRSF1B, ETS2, ETS1, TNFRSF8, CD40, HTNVsSgp1,
Protein Size: 362

Molecular Weight: 41 kDa

Gene ID: 51567

NCBI Accession: NM_016614, NP_057698

UniProt: O95551