SMARCE1 antibody (N-Term)

Catalog No. ABIN2777857

This anti-SMARCE1 antibody is a Rabbit Polyclonal antibody detecting SMARCE1 in WB. Suitable for Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Guinea Pig and Pig.

Quick Overview for SMARCE1 antibody (N-Term) (ABIN2777857)

Target: SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily E, Member 1 (SMARCE1))

Reactivity: Human, Mouse, Rat, Rabbit, Dog, Horse, Cow, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMARCE1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SMARCE1 Antibody

Binding Specificity: N-Term

Sequence: EEREKEAAEQ AERSQSSIVP EEEQAANKGE EKKDDENIPM ETEETHLEET

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 77%, Horse: 92%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 85%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against SMARCE1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SMARCE1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 411 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMARCE1

Target: SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily E, Member 1 (SMARCE1))

Alternative Name: SMARCE1

Background: SMARCE1 is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-72 BQ707908.1 667-738 73-2415 AK095047.1 40-2382 2416-2425 BC063700.1 2379-2388
Alias Symbols: BAF57
Protein Interaction Partner: NOTCH2NL, KRTAP10-9, CCDC172, NBPF22P, TXLNA, MIPOL1, KRT40, MRFAP1L1, SYCE1, ING5, USHBP1, CEP70, CEP63, CCDC136, RINT1, TRIM54, AMOTL2, MED4, TFIP11, NUP62, MTUS2, EXOC7, RALBP1, SPAG5, JAKMIP2, TRIP10, STX11, CEP170P1, MEOX2, KRT31, KRT15, KIFC3, GOLGA
Protein Size: 411

Molecular Weight: 47 kDa

Gene ID: 6605

NCBI Accession: NM_003079, NP_003070

UniProt: Q969G3

Pathways: Chromatin Binding