T-Box 1 antibody (C-Term)

Catalog No. ABIN2777912

This anti-T-Box 1 antibody is a Rabbit Polyclonal antibody detecting T-Box 1 in WB and IHC. Suitable for Human, Mouse, Rat, Guinea Pig, Rabbit and Dog.

Quick Overview for T-Box 1 antibody (C-Term) (ABIN2777912)

Target: T-Box 1 (TBX1)

Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This T-Box 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-T-Box 1 Antibody

Binding Specificity: C-Term

Sequence: PNPELRLEAP GASEPLHHHP YKYPAAAYDH YLGAKSRPAP YPLPGLRGHG

Predicted Reactivity: Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TBX1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TBX1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 495 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for T-Box 1

Target: T-Box 1 (TBX1)

Alternative Name: TBX1

Background: TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX1 product shares 98 % amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where TBX1 has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: DGS, TGA, CAFS, CTHM, DGCR, DORV, VCFS, TBX1C
Protein Interaction Partner: TERF2, TERF1,
Protein Size: 495

Molecular Weight: 53 kDa

Gene ID: 6899

NCBI Accession: NM_080647, NP_542378

Pathways: Retinoic Acid Receptor Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation