T-Box 6 antibody (N-Term)

Catalog No. ABIN2777918

The Rabbit Polyclonal anti-T-Box 6 antibody has been validated for WB and IHC. It is suitable to detect T-Box 6 in samples from Human, Mouse, Rat, Horse, Pig, Cow, Dog and Guinea Pig. There are 2+ publications available.

Quick Overview for T-Box 6 antibody (N-Term) (ABIN2777918)

Target: T-Box 6 (TBX6)

Reactivity: Human, Mouse, Rat, Horse, Pig, Cow, Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This T-Box 6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-T-Box 6 Antibody

Binding Specificity: N-Term

Sequence: AHPPLPLLPP AMGTEPAPSA PEALHSLPGV SLSLENRELW KEFSSVGTEM

Predicted Reactivity: Cow: 92%, Dog: 92%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TBX6. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TBX6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 436 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-T-Box 6 antibody (ABIN2777918)

Chen, Liu, Zhou, Hu, Fei, Xie, Ding: "Smad6 inhibits the transcriptional activity of Tbx6 by mediating its degradation." in: The Journal of biological chemistry, Vol. 284, Issue 35, pp. 23481-90, (2009) (PubMed).

Leschik, Stefanovic, Brinon, Pucéat: "Cardiac commitment of primate embryonic stem cells." in: Nature protocols, Vol. 3, Issue 9, pp. 1381-7, (2008) (PubMed).

Target Details for T-Box 6

Target: T-Box 6 (TBX6)

Alternative Name: TBX6

Background: The TBX6 gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX6 is the human ortholog of mouse Tbx6. Knockout experiments in mice indicate that Tbx6 is important for specification of paraxial mesoderm structures.
Alias Symbols: DFNB67
Protein Interaction Partner: HSFY1, C1orf94, RBPMS, TOX4, PSMA3, MEOX2, PRMT1,
Protein Size: 436

Molecular Weight: 47 kDa

Gene ID: 6911

NCBI Accession: NM_004608, NP_004599

UniProt: O95947