TWIST1 antibody (N-Term)

Catalog No. ABIN2777932

The Rabbit Polyclonal anti-TWIST1 antibody is suitable to detect TWIST1 in samples from Human, Mouse, Rat, Cow, Horse and Zebrafish (Danio rerio). It has been validated for WB.

Quick Overview for TWIST1 antibody (N-Term) (ABIN2777932)

Target: TWIST1 (Twist Homolog 1 (Drosophila) (TWIST1))

Reactivity: Human, Mouse, Rat, Cow, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TWIST1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TWIST1 Antibody

Binding Specificity: N-Term

Sequence: DSLSNSEEEP DRQQPPSGKR GGRKRRSSRR SAGGGAGPGG AAGGGVGGGD

Predicted Reactivity: Cow: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against TWIST1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human TWIST1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TWIST1

Target: TWIST1 (Twist Homolog 1 (Drosophila) (TWIST1))

Alternative Name: TWIST1

Background: Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue, in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.
Alias Symbols: ACS3, BPES2, BPES3, CRS1, SCS, TWIST, bHLHa38
Protein Interaction Partner: UBC, HOXA5, ETS2, TP53, KAT2B, SETD8, HES6, MTA2, BRAP, TCF3, RELA, PPP2CA, HDAC2, CHD3, TWIST2, ELSPBP1, WDR5, HDAC3, RBBP7, CHD4, SOX2, EP300, TWIST1, GLI3, MYOD1,
Protein Size: 202

Molecular Weight: 22 kDa

Gene ID: 7291

NCBI Accession: NM_000474, NP_000465

UniProt: Q15672

Pathways: p53 Signaling, Proton Transport, Tube Formation, Negative Regulation of Transporter Activity