DACH1 antibody (C-Term)

Catalog No. ABIN2778444

Product Details anti-DACH1 Antibody

Target: DACH1 (Dachshund 1 (DACH1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Horse, Rabbit, Guinea Pig, Dog, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DACH1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TLKQAASTDS LRVLNDSLTP EIEADRSGGR TDAERTIQDG RLYLKTTVMY

Predicted Reactivity: Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against DACH1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DACH1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 558 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DACH1

Target: DACH1 (Dachshund 1 (DACH1))

Alternative Name: DACH1 (DACH1 Products)

Background: This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: DACH, FLJ10138
Protein Interaction Partner: C1orf35, NAGK, ZCCHC10, U2AF2, AHCYL1, RNF14, PPIG, FGF12, DACH1, UBE2I, SMAD4, SMAD3, SIN3A, NCOR1, UBC, JUN, CREB1, HDAC3, HDAC1, EYA3, EYA1, SIX1, CREBBP,
Protein Size: 558

Molecular Weight: 57 kDa

Gene ID: 1602

NCBI Accession: NM_080760, NP_542938

UniProt: Q9UI36

Pathways: Feeding Behaviour