MLX antibody (C-Term)

Catalog No. ABIN2778546

The Rabbit Polyclonal anti-MLX antibody has been validated for WB and IHC. It is suitable to detect MLX in samples from Human, Mouse, Rat, Cow, Dog, Pig, Goat, Horse, Rabbit and Zebrafish (Danio rerio). There is 1 publication available.

Quick Overview for MLX antibody (C-Term) (ABIN2778546)

Target: MLX (MAX-Like Protein X (MLX))

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Goat, Horse, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLX antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-MLX Antibody

Binding Specificity: C-Term

Sequence: LRKDVTALKI MKVNYEQIVK AHQDNPHEGE DQVSDQVKFN VFQGIMDSLF

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against MLX. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MLX

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 298 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-MLX antibody (ABIN2778546)

Stoltzman, Peterson, Breen, Muoio, Billin, Ayer: "Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 19, pp. 6912-7, (2008) (PubMed).

Target Details for MLX

Target: MLX (MAX-Like Protein X (MLX))

Alternative Name: MLX

Background: MLX belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. MLX may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4.The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Alias Symbols: MAD7, MXD7, TCFL4, bHLHd13
Protein Interaction Partner: ZBTB32, GABARAPL2, RBM39, AES, UBC, SAP30BP, ID3, APP, SUMO1, MLXIPL, MLXIP, MXD4, MNT, MAD1L1, MLX, MXD1,
Protein Size: 298

Molecular Weight: 33 kDa

Gene ID: 6945

NCBI Accession: NM_170607, NP_733752

UniProt: Q9UH92