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INSIG1 antibody (Insulin Induced Gene 1) (Middle Region) Primary Antibody

INSIG1 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2778635
$389.00
Plus shipping costs $45.00
100 μL
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  • Target
    INSIG1
    Binding Specificity
    • 8
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 29
    • 9
    • 8
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 30
    Rabbit
    Clonality
    • 30
    Polyclonal
    Conjugate
    • 17
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    This INSIG1 antibody is un-conjugated
    Application
    • 27
    • 18
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    TTWLFHKTRS NYRVFLKSPI VIESSKPPIL RARKILEENL TVDYDKDYLF
    Predicted Reactivity
    Human: 100%, Mouse: 82%
    Characteristics
    This is a rabbit polyclonal antibody against INSIG1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human INSIG1
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 330 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    INSIG1
    Alternative Name
    INSIG1 (INSIG1 Antibody Abstract)
    Synonyms
    cl-6, cl6, CL-6, CL6, fb55a03, fi35b10, wu:fb55a03, wu:fi35b10, zgc:55439, 1810013C12Rik, Insig-1, INSIG-1, insulin induced gene 1, insulin induced gene 1 L homeolog, INSIG1, insig1, insig1.L, Insig1
    Background
    Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
    Alias Symbols: CL-6, MGC1405, CL6
    Protein Interaction Partner: UBC, HMGCR, FAF2, SCAP, ERLIN2, ERLIN1, VCP, AMFR, PGRMC1, POR, SREBF1, ELAVL1, RNF139, INSIG2, PSMC3, PSMA7, INSIG1, VAPA, VAPB, SREBF2,
    Protein Size: 330
    Molecular Weight
    36 kDa
    Gene ID
    3638
    NCBI Accession
    NM_198336, NP_938150
    UniProt
    A4D2M9
    Pathways
    ER-Nucleus Signaling
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