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INSIG1 antibody (Middle Region)

INSIG1 Reactivity: Human, Mouse, Rat, Cow, Goat, Horse, Rabbit, Dog, Guinea Pig, Sheep, Pig, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2778638
  • Target See all INSIG1 Antibodies
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    Binding Specificity
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 28
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Cow, Goat, Horse, Rabbit, Dog, Guinea Pig, Sheep, Pig, Zebrafish (Danio rerio)
    Host
    • 28
    Rabbit
    Clonality
    • 28
    Polyclonal
    Conjugate
    • 16
    • 4
    • 2
    • 2
    • 2
    • 2
    This INSIG1 antibody is un-conjugated
    Application
    • 24
    • 17
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    WWVPPCCGTA SAVIGLLYPC IDRHLGEPHK FKREWSSVMR CVAVFVGINH
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 87%
    Characteristics
    This is a rabbit polyclonal antibody against INSIG1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human INSIG1
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    Discover our top product INSIG1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 225 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    INSIG1 (Insulin Induced Gene 1 (INSIG1))
    Alternative Name
    INSIG1 (INSIG1 Products)
    Synonyms
    cl-6 antibody, cl6 antibody, CL-6 antibody, CL6 antibody, fb55a03 antibody, fi35b10 antibody, wu:fb55a03 antibody, wu:fi35b10 antibody, zgc:55439 antibody, 1810013C12Rik antibody, Insig-1 antibody, INSIG-1 antibody, insulin induced gene 1 antibody, insulin induced gene 1 L homeolog antibody, INSIG1 antibody, insig1 antibody, insig1.L antibody, Insig1 antibody
    Background
    Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. INSIG1 is an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. INSIG1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
    Alias Symbols: MGC26273, INSIG1
    Protein Interaction Partner: RNF5, HMGCR, SCAP, SREBF1, RNF139, UBQLN1, UBQLN2, FAF2, ADRM1, PSMD14, BAG6, VCP, UBC, RPN1, PSMD13, PSMD12, PSMD11, PSMD4, PSMC6, PSMC5, PSMC3, PSMC2, PSMB3, PSMB1, PSMA7, PSMA2, LGALS7, JUP, INSIG1, HSPA8, HSPA6, HSPA5, HSPA1A, ENO1, DSP, AMFR, SREBF2,
    Protein Size: 225
    Molecular Weight
    25 kDa
    Gene ID
    51141
    NCBI Accession
    NM_016133, NP_057217
    UniProt
    Q9Y5U4
    Pathways
    ER-Nucleus Signaling
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