SMNDC1 antibody (Middle Region)

Catalog No. ABIN2778955

The Rabbit Polyclonal anti-SMNDC1 antibody has been validated for WB and IHC. It is suitable to detect SMNDC1 in samples from Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Goat, Horse and Zebrafish (Danio rerio).

Quick Overview for SMNDC1 antibody (Middle Region) (ABIN2778955)

Target: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Rabbit, Guinea Pig, Goat, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMNDC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SMNDC1 Antibody

Binding Specificity: Middle Region

Sequence: QFNNRAYSKN KKGQVKRSIF ASPESVTGKV GVGTCGIADK PMTQYQDTSK

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Characteristics: This is a rabbit polyclonal antibody against SMNDC1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SMNDC1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 238 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SMNDC1

Target: SMNDC1 (Survival Motor Neuron Domain Containing 1 (SMNDC1))

Alternative Name: SMNDC1

Background: This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. SMNDC1 is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. This gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene.
Alias Symbols: SMNR, SPF30
Protein Interaction Partner: UBC, PRPF3, SF3B5, SND1, CUL3, SF3A2, ELAVL1, HIST3H3, mad2, KPNB1, SNRNP200, SNRPB, CDK5RAP3, PPAN, TSR1, RNMTL1, SF3B1, SF3B3, SF3B2, SF3A3, SF3B4, DDX21, RUVBL1, RPL3, FDFT1, EWSR1,
Protein Size: 238

Molecular Weight: 27 kDa

Gene ID: 10285

NCBI Accession: NM_005871, NP_005862

UniProt: O75940