SFRS6 antibody (Middle Region)

Catalog No. ABIN2778972

This Rabbit Polyclonal antibody specifically detects SFRS6 in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Horse, Pig, Rabbit, Zebrafish (Danio rerio), Dog and Guinea Pig and has been mentioned in 2+ publications.

Quick Overview for SFRS6 antibody (Middle Region) (ABIN2778972)

Target: SFRS6 (SRSF6) (serine/arginine-Rich Splicing Factor 6 (SRSF6))

Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Rabbit, Zebrafish (Danio rerio), Dog, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SFRS6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SFRS6 Antibody

Binding Specificity: Middle Region

Sequence: KERTNEGVIE FRSYSDMKRA LDKLDGTEIN GRNIRLIEDK PRTSHRRSYS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 82%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against SFRS6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SFRS6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 344 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SFRS6 antibody (ABIN2778972)

Gautrey, Tyson-Capper: "Regulation of Mcl-1 by SRSF1 and SRSF5 in cancer cells." in: PLoS ONE, Vol. 7, Issue 12, pp. e51497, (2013) (PubMed).

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Target Details for SFRS6

Target: SFRS6 (SRSF6) (serine/arginine-Rich Splicing Factor 6 (SRSF6))

Alternative Name: SFRS6

Background: SFRS6 is involved in mRNA splicing and may play a role in the determination of alternative splicing. It belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12.The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: B52, MGC5045, SRP55, SFRS6
Protein Interaction Partner: LUC7L2, TP53, MDM2, ASB18, SUZ12, EED, RPL24, SRPK2, SRPK1, SRPK3, TARDBP, YWHAE, PAN2, TOE1, SF3B4, RBM10, UBC, TRA2B, EIF4A3, MAGOH, ESR1, BARD1, SRSF10, APP, CAND1, COPS5, SRRM1, CUL1, CUL2, TERF2, TERF1, HNRNPA1, SF3A2, ELAVL1, SREK1, AI837181, CLK1,
Protein Size: 344

Molecular Weight: 39 kDa

Gene ID: 6431

NCBI Accession: NM_006275, NP_006266

UniProt: Q13247

Pathways: Ribonucleoprotein Complex Subunit Organization