Amphiregulin antibody (Middle Region)

Catalog No. ABIN2779308

This Rabbit Polyclonal antibody specifically detects Amphiregulin in WB. It exhibits reactivity toward Human, Cow, Horse, Pig, Dog and Sheep.

Quick Overview for Amphiregulin antibody (Middle Region) (ABIN2779308)

Target: Amphiregulin (AREG)

Reactivity: Human, Cow, Horse, Pig, Dog, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Amphiregulin antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Amphiregulin Antibody

Binding Specificity: Middle Region

Sequence: PQIPGYIVDD SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR

Predicted Reactivity: Cow: 91%, Dog: 91%, Horse: 91%, Human: 100%, Pig: 91%, Sheep: 91%

Characteristics: This is a rabbit polyclonal antibody against AREG. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human AREG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 252 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Amphiregulin

Target: Amphiregulin (AREG)

Alternative Name: AREG

Background: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.
Alias Symbols: AR, AREGB, CRDGF, MGC13647, SDGF
Protein Interaction Partner: KRTAP10-3, WDR92, UBC, APP, UBQLN4, WT1, EGFR, CCND3, MMP9,
Protein Size: 252

Molecular Weight: 28 kDa

Gene ID: 374

NCBI Accession: NM_001657, NP_001648

UniProt: P15514

Pathways: RTK Signaling, EGFR Signaling Pathway