TRAF6 antibody (C-Term)

Catalog No. ABIN2500630

The Rabbit Polyclonal anti-TRAF6 antibody (ABIN2500630) specifically detects TRAF6 in WB. The antibody is reactive with Human, Mouse, Rat, Rabbit, Cow, Pig and Horse samples.

Quick Overview for TRAF6 antibody (C-Term) (ABIN2500630)

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Reactivity: Human, Mouse, Rat, Rabbit, Cow, Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAF6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRAF6 Antibody

Binding Specificity: C-Term

Sequence: FGYVTFMHLE ALRQRTFIKD DTLLVRCEVS TRFDMGSLRR EGFQPRSTDA

Predicted Reactivity: Cow: 100%, Horse: 100%, Human: 100%, Mouse: 91%, Pig: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TRAF6. It was validated on Western Blot.

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human TRAF6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRAF6

Target: TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))

Alternative Name: TRAF6

Background: TRAF6 is an E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. It also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. It may be essential for the formation of functional osteoclasts. It seems to also play a role in dendritic cells (DCs) maturation and/or activation. It represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. It regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.
Alias Symbols: MGC:3310, RNF85
Protein Interaction Partner: YES1, UBE2V1, UBE2N, UBE2L3, UBE2E1, UBE2D2, UBE2D1, POLI, UBC, IL1R1, EDARADD, PLEKHF2, LAT, TRAF3IP2, PPP4R1, USP2, IKBKG, TRAF6, TRAF5, TRAF2, TRAF1, CNTN2, SYK, VPS52, PSEN1, LGMN, MEOX2, MCL1, CANX, nef, TAB2, OTUD7A, GTF2I, KRAS, DCBLD2, MAP3K7, EIF
Protein Size: 522

Molecular Weight: 57 kDa

Gene ID: 7189

NCBI Accession: NM_004620, NP_004611

UniProt: Q9Y4K3

Pathways: NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway