BAK1 antibody (N-Term)

Catalog No. ABIN2779335

This anti-BAK1 antibody is a Rabbit Polyclonal antibody detecting BAK1 in WB. Suitable for Human and Horse.

Quick Overview for BAK1 antibody (N-Term) (ABIN2779335)

Target: BAK1 (BCL2-Antagonist/killer 1 (BAK1))

Reactivity: Human, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BAK1 Antibody

Binding Specificity: N-Term

Sequence: ASGQGPGPPR QECGEPALPS ASEEQVAQDT EEVFRSYVFY RHQQEQEAEG

Predicted Reactivity: Horse: 80%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against BAK1. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 211 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for BAK1

Target: BAK1 (BCL2-Antagonist/killer 1 (BAK1))

Alternative Name: BAK1

Background: BAK1 belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
Alias Symbols: BAK, BAK-LIKE, BCL2L7, CDN1, MGC117255, MGC3887
Protein Interaction Partner: BCL2L2, BCL2A1, BCL2L1, BMH1, NFKBIB, HSD17B4, TOMM7, ABCB10, TOMM40, TP53, BAX, MCL1, UBC, DBN1, ARHGDIA, MFN1, BCL2L10, VDAC1, ERN1, BID, BAK1, VDAC2, BCL2, HSPD1, FRYL, SRRM2, MYCBP2, AKAP13, ACTR2, KRT31, FBL, DFFA,
Protein Size: 211

Molecular Weight: 23 kDa

Gene ID: 578

NCBI Accession: NM_001188, NP_001179

UniProt: Q16611

Pathways: Apoptosis, Steroid Hormone Mediated Signaling Pathway, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response