beta Arrestin 1 antibody (Middle Region)

Catalog No. ABIN2779340

This Rabbit Polyclonal antibody specifically detects beta Arrestin 1 in WB. It exhibits reactivity toward Human, Cow, Horse and Dog.

Quick Overview for beta Arrestin 1 antibody (Middle Region) (ABIN2779340)

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Reactivity: Human, Cow, Horse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta Arrestin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-beta Arrestin 1 Antibody

Binding Specificity: Middle Region

Sequence: NETPVDTNLI ELDTNDDDIV FEDFARQRLK GMKDDKEEEE DGTGSPQLNN

Predicted Reactivity: Cow: 90%, Dog: 100%, Horse: 100%, Human: 100%

Characteristics: This is a rabbit polyclonal antibody against ARRB1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ARRB1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 418 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for beta Arrestin 1

Target: beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

Alternative Name: ARRB1

Background: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.
Alias Symbols: ARB1, ARR1
Protein Interaction Partner: MAPK9, UBC, PTGER4, SRC, GNMT, NOTCH1, ARRDC1, PTAFR, MAP2K3, LIMK1, PDXP, MAPK14, CLTC, CFL1, AP2A1, MAP3K5, AKT1, AGTR1, MAP2K4, MAPK10, CSK, EDNRA, Agtr1a, NEK6, PIK3R2, NFKBIA, AXIN1, YY1, BTK, BAG1, ADRB1, ADH6, RPL15, PDE4D, Mlnr, Trhr, ARRDC4, ARRD
Protein Size: 418

Molecular Weight: 47 kDa

Gene ID: 408

NCBI Accession: NM_004041, NP_004032

UniProt: P49407

Pathways: Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction