YWHAB antibody (Middle Region)

Catalog No. ABIN2779358

This Rabbit Polyclonal antibody specifically detects YWHAB in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog, Sheep, Guinea Pig, Rabbit and Horse.

Quick Overview for YWHAB antibody (Middle Region) (ABIN2779358)

Target: YWHAB (14-3-3 alpha + beta (YWHAB))

Reactivity: Human, Mouse, Rat, Cow, Dog, Sheep, Guinea Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This YWHAB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-YWHAB Antibody

Binding Specificity: Middle Region

Sequence: KTERNEKKQQ MGKEYREKIE AELQDICNDV LELLDKYLIP NATQPESKVF

Predicted Reactivity: Cow: 87%, Dog: 87%, Guinea Pig: 87%, Horse: 80%, Human: 87%, Mouse: 87%, Rabbit: 87%, Rat: 87%, Sheep: 87%

Characteristics: This is a rabbit polyclonal antibody against YWHAB. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human YWHAB

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 246 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for YWHAB

Target: YWHAB (14-3-3 alpha + beta (YWHAB))

Alternative Name: YWHAB

Background: YWHAB belongs to the 14-3-3 family, members of which mediate signal transduction by binding to phosphoserine-containing proteins. YWHAB has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery.
Alias Symbols: GW128, HS1, KCIP-1, YWHAA
Protein Interaction Partner: ZFP36, UBC, DDIT4, DTL, Crtc2, ABL1, SIK3, SUMO2, IRS4, LDHB, DAK, SMS, SGTA, PGD, PAK2, PAFAH1B2, YWHAQ, TUBB4B, RRAGB, SLC9A3R1, BCCIP, GSS, G6PD, CAPZA1, LRRK2, MARK3, CBL, ZFP36L2, BRAF, BAD, ARAF, AMPD2, PKP2, PI4KB, PIK3C2A, PFKFB2, CDK18, CDK17, CD
Protein Size: 246

Molecular Weight: 28 kDa

Gene ID: 7529

NCBI Accession: NM_003404, NP_003395

UniProt: P31946

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, Maintenance of Protein Location