DYRK3 antibody (N-Term)

Catalog No. ABIN2779363

The Rabbit Polyclonal anti-DYRK3 antibody has been validated for WB. It is suitable to detect DYRK3 in samples from Human, Rat, Guinea Pig and Saccharomyces cerevisiae.

Quick Overview for DYRK3 antibody (N-Term) (ABIN2779363)

Target: DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))

Reactivity: Human, Rat, Guinea Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYRK3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DYRK3 Antibody

Binding Specificity: N-Term

Sequence: EPPPPRRLNM TTEQFTGDHT QHFLDGGEMK VEQLFQEFGN RKSNTIQSDG

Predicted Reactivity: Guinea Pig: 83%, Human: 100%, Rat: 90%, Yeast: 80%

Characteristics: This is a rabbit polyclonal antibody against DYRK3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DYRK3

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 568 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for DYRK3

Target: DYRK3 (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 3 (DYRK3))

Alternative Name: DYRK3

Background: This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: DYRK5, RED, REDK, hYAK3-2
Protein Interaction Partner: DYRK3, SORL1, FBXO25, PRNP, NEDD4L,
Protein Size: 568

Molecular Weight: 64 kDa

Gene ID: 8444

NCBI Accession: NM_001004023, NP_001004023

UniProt: D3DT79

Pathways: Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha