NFKB2 antibody (C-Term)

Catalog No. ABIN2779436

The Rabbit Polyclonal anti-NFKB2 antibody has been validated for WB and IHC. It is suitable to detect NFKB2 in samples from Human, Rat, Cow, Pig, Rabbit and Horse. There are 2+ publications available.

Quick Overview for NFKB2 antibody (C-Term) (ABIN2779436)

Target: NFKB2 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))

Reactivity: Human, Rat, Cow, Pig, Rabbit, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFKB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-NFKB2 Antibody

Binding Specificity: C-Term

Sequence: SDSDSDSEGP EKDTRSSFRG HTPLDLTCST LVKTLLLNAA QNTMEPPL

Predicted Reactivity: Cow: 77%, Horse: 85%, Human: 100%, Pig: 77%, Rabbit: 92%, Rat: 77%

Characteristics: This is a rabbit polyclonal antibody against NFKB2. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human NFKB2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 933 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-NFKB2 antibody (ABIN2779436)

Wang, Yang, Li, Gong: "Characterization of a negative feedback network between SUMO4 expression and NFkappaB transcriptional activity." in: Biochemical and biophysical research communications, Vol. 381, Issue 4, pp. 477-81, (2009) (PubMed).

Volger, Fledderus, Kisters, Fontijn, Moerland, Kuiper, van Berkel, Bijnens, Daemen, Pannekoek, Horrevoets: "Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis." in: The American journal of pathology, Vol. 171, Issue 1, pp. 326-37, (2007) (PubMed).

Target Details for NFKB2

Target: NFKB2 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))

Alternative Name: NFKB2

Background: NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth.
Alias Symbols: p52, H2TF1, LYT10, LYT-10
Protein Interaction Partner: FBXW11, UBC, RELB, RELA, REL, NFKB1, CHUK, BCL3, SUMO1, NEDD8, TNFAIP3, BIRC2, EPS8, VCP, UBD, BRRF1, COMMD1, COMMD2, MAP3K14, BTRC, NFKB2, FBXW7, TSG101, IKBKG, SUMO2, DPF2, PSMD11, NFKBIZ, TNIP2, HDAC5, NFKBIB, HDAC4, USP2, NFKBIE, RPL6, IKBKB, TSC22D3,
Protein Size: 900

Molecular Weight: 97 kDa

Gene ID: 4791

NCBI Accession: NM_002502, NP_002493

UniProt: Q00653

Pathways: Toll-Like Receptors Cascades