GSC antibody (N-Term)

Catalog No. ABIN2779490

This anti-GSC antibody is a Rabbit Polyclonal antibody detecting GSC in WB and IHC. Suitable for Human, Rat, Mouse, Cow, Dog and Pig. This Primary Antibody has been cited in 1 publication.

Quick Overview for GSC antibody (N-Term) (ABIN2779490)

Target: GSC (Goosecoid Homeobox (GSC))

Reactivity: Human, Rat, Mouse, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-GSC Antibody

Binding Specificity: N-Term

Sequence: FPALHGDSLY GASGGASSDY GAFYPRPVAP GGAGLPAAVS GSRLGYNNYF

Predicted Reactivity: Cow: 86%, Dog: 92%, Human: 100%, Mouse: 85%, Pig: 100%, Rat: 85%

Characteristics: This is a rabbit polyclonal antibody against GSC. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human GSC

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 257 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-GSC antibody (ABIN2779490)

Behl, Hsieh, Shafer, Mundy, Rice, Boyd, Freedman, Hunter, Jarema, Padilla, Tice: "Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity." in: Neurotoxicology and teratology, Vol. 52, Issue Pt B, pp. 181-93, (2015) (PubMed).

Target Details for GSC

Target: GSC (Goosecoid Homeobox (GSC))

Alternative Name: GSC

Background: GSC regulates chordin (CHRD). GSC may play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis.This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis.
Alias Symbols: -
Protein Interaction Partner: SMAD3, SMAD1, SMAD2, FOXA2,
Protein Size: 257

Molecular Weight: 28 kDa

Gene ID: 145258

NCBI Accession: NM_173849, NP_776248

UniProt: P56915