ESRRA antibody (C-Term)

Catalog No. ABIN2779529

This anti-ESRRA antibody is a Rabbit Polyclonal antibody detecting ESRRA in WB. Suitable for Human, Mouse, Rat, Dog, Cow, Horse and Guinea Pig.

Quick Overview for ESRRA antibody (C-Term) (ABIN2779529)

Target: ESRRA (Estrogen-Related Receptor alpha (ESRRA))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ESRRA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ESRRA Antibody

Binding Specificity: C-Term

Sequence: AGRAGPGGGA ERRRAGRLLL TLPLLRQTAG KVLAHFYGVK LEGKVPMHKL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against Esrra. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide corresponding to a region of Mouse

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 422 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ESRRA

Target: ESRRA (Estrogen-Related Receptor alpha (ESRRA))

Alternative Name: Esrra

Background: Esrra binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. It can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. It binds to the C1 region of the lactoferrin gene promoter. It requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism.
Alias Symbols: ERRalpha, Err1, Estrra, Nr3b1
Protein Interaction Partner: Ubc, Sirt1, Hdac8, Kat2b, Crebzf, Esrrb, Ppargc1a,
Protein Size: 422

Molecular Weight: 45 kDa

Gene ID: 26379

NCBI Accession: NM_007953, NP_031979

UniProt: O08580

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha