HDAC2 antibody (C-Term)

Catalog No. ABIN2779752

This Rabbit Polyclonal antibody specifically detects HDAC2 in WB and IHC. It exhibits reactivity toward Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Dog, Horse, Pig and Saccharomyces cerevisiae.

Quick Overview for HDAC2 antibody (C-Term) (ABIN2779752)

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Guinea Pig, Dog, Horse, Pig, Saccharomyces cerevisiae

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HDAC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-HDAC2 Antibody

Binding Specificity: C-Term

Sequence: EEFSDSEDEG EGGRRNVADH KKGAKKARIE EDKKETEDKK TDVKEEDKSK

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 91%

Characteristics: This is a rabbit polyclonal antibody against HDAC2. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human HDAC2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 488 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for HDAC2

Target: HDAC2 (Histone Deacetylase 2 (HDAC2))

Alternative Name: HDAC2

Background: Histone deacetylase 2 (HDAC2), or transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely to be involved in regulating chromatin structure during transcription. It has been implicated to associate with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. This process is highly concerved from yeast to human.
Alias Symbols: HD2, RPD3, YAF1
Protein Interaction Partner: BRCA1, SUMO1, UBC, SMAD7, SMAD2, MXD1, NCOR2, SUMO2, SFPQ, KDM5A, HDAC1, DDB1, CUL4B, CHFR, KDM1A, KDM5B, NFE2L2, PRDM6, DNMT3B, DNMT1, NACC2, HIST1H4A, HIST1H3A, HIST2H2BE, HIST2H2AC, PRDM1, EED, RNF2, SP1, CHD4, CHD3, ACTL6A, C16orf87, HMG20A, HMG20B, C
Protein Size: 488

Molecular Weight: 55 kDa

Gene ID: 3066

NCBI Accession: NM_001527, NP_001518

UniProt: Q92769

Pathways: Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection