TRIM23 antibody (Middle Region)

Catalog No. ABIN2779792

The Rabbit Polyclonal anti-TRIM23 antibody (ABIN2779792) specifically detects TRIM23 in WB. The antibody is reactive with Human, Rat, Mouse, Dog, Guinea Pig, Horse, Rabbit, Cow and Zebrafish (Danio rerio) samples.

Quick Overview for TRIM23 antibody (Middle Region) (ABIN2779792)

Target: TRIM23 (Tripartite Motif Containing 23 (TRIM23))

Reactivity: Human, Rat, Mouse, Dog, Guinea Pig, Horse, Rabbit, Cow, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM23 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TRIM23 Antibody

Binding Specificity: Middle Region

Sequence: KHSVLEPEAN QIRASILDMA HCIRTFTEEI SDYSRKLVGI VQHIEGGEQI

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Characteristics: This is a rabbit polyclonal antibody against TRIM23. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TRIM23

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 546 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TRIM23

Target: TRIM23 (Tripartite Motif Containing 23 (TRIM23))

Alternative Name: TRIM23

Background: TRIM23 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described.
Alias Symbols: ARD1, ARFD1, RNF46
Protein Interaction Partner: LGALS8, TNFAIP3, TMSB4X, SNRPB, SNAI1, SNAI2, SIAH1, PSMA1, PIK3R2, PHF1, LMO2, FAM90A1, KRT6A, KIFC3, HOXB5, COX5B, CDR2, BAG1, TRIM23, AQP1, SLC25A6, FAM208B, FAM193B, ZNF581, SPG21, MRPL4, ARHGEF3, POLL, NFU1, GPKOW, HSPB7, PPIL2, TRIM29, DMC1, USP20,
Protein Size: 546

Molecular Weight: 61 kDa

Gene ID: 373

NCBI Accession: NM_033228, NP_150231