SCN3B antibody (N-Term)

Catalog No. ABIN183548

There are 3+ publications for this product available. The Rabbit Polyclonal anti-SCN3B antibody is suitable to detect SCN3B in samples from Rat, Human, Mouse, Cow, Dog, Guinea Pig, Horse and Rabbit. It has been validated for WB.

Quick Overview for SCN3B antibody (N-Term) (ABIN183548)

Target: SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))

Reactivity: Rat, Human, Mouse, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCN3B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SCN3B Antibody

Binding Specificity: N-Term

Sequence: RPEGGKDFLI YEYRNGHQEV ESPFQGRLQW NGSKDLQDVS ITVLNVTLND

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SCN3B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SCN3B

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 215 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-SCN3B antibody (ABIN183548)

Ho, Zhao, Malinowski, Chahine, OLeary: "Differential expression of sodium channel ? subunits in dorsal root ganglion sensory neurons." in: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 15044-53, (2012) (PubMed).

Hu, Barajas-Martinez, Burashnikov, Springer, Wu, Varro, Pfeiffer, Koopmann, Cordeiro, Guerchicoff, Pollevick, Antzelevitch: "A mutation in the beta 3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype." in: Circulation. Cardiovascular genetics, Vol. 2, Issue 3, pp. 270-8, (2009) (PubMed).

Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

Target Details for SCN3B

Target: SCN3B (Sodium Channel, Voltage-Gated, Type III, beta Subunit (SCN3B))

Alternative Name: SCN3B

Background: SCN3B is one member of the sodium channel beta subunits of voltage-gated sodium channels, which are responsible for the generation and propagation of action potentials in neurons and muscle. SCN3B influences the inactivation kinetics of the sodium channel.
Alias Symbols: HSA243396, SCNB3
Protein Interaction Partner: NFASC,
Protein Size: 215

Molecular Weight: 24 kDa

Gene ID: 55800

NCBI Accession: NM_018400, NP_060870

UniProt: Q9NY72