Fibrillin 1 antibody (N-Term)

Catalog No. ABIN2780329

The Rabbit Polyclonal anti-Fibrillin 1 antibody has been validated for WB. It is suitable to detect Fibrillin 1 in samples from Human, Mouse, Rat, Cow, Pig, Dog, Horse, Guinea Pig and Rabbit.

Quick Overview for Fibrillin 1 antibody (N-Term) (ABIN2780329)

Target: Fibrillin 1 (FBN1)

Reactivity: Human, Mouse, Rat, Cow, Pig, Dog, Horse, Guinea Pig, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Fibrillin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Fibrillin 1 Antibody

Binding Specificity: N-Term

Sequence: MRRGRLLEIA LGFTVLLASY TSHGADANLE AGNVKETRAS RAKRRGGGGH

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 93%, Rabbit: 100%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against FBN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human FBN1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 195 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Fibrillin 1

Target: Fibrillin 1 (FBN1)

Alternative Name: FBN1

Background: FBN1 is a member of the fibrillin family. FBN1 is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome.
Alias Symbols: FBN, SGS, WMS, MASS, MFS1, OCTD, SSKS, WMS2, ACMICD, GPHYSD2
Protein Interaction Partner: UBC, SPRY2, ATXN7, MYOC, MFAP5, MFAP2, LTBP1, HSPG2, FBLN2, ELN, DCN, FBN2, VCAN, CALR,
Protein Size: 195

Molecular Weight: 21 kDa

Gene ID: 2200

NCBI Accession: NM_000138

UniProt: Q75N89

Pathways: Maintenance of Protein Location, SARS-CoV-2 Protein Interactome