MAX antibody (Middle Region)

Catalog No. ABIN2780421

The Rabbit Polyclonal anti-MAX antibody has been validated for WB. It is suitable to detect MAX in samples from Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Guinea Pig, Horse and Rabbit.

Quick Overview for MAX antibody (Middle Region) (ABIN2780421)

Target: MAX (MYC Associated Factor X (MAX))

Reactivity: Human, Mouse, Rat, Dog, Cow, Zebrafish (Danio rerio), Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAX Antibody

Binding Specificity: Middle Region

Sequence: LQTNYPSSDN SLYTNAKGST ISAFDGGSDS SSESEPEEPQ SRKKLRMEAS

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against MAX. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MAX

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 160 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MAX

Target: MAX (MYC Associated Factor X (MAX))

Alternative Name: MAX

Background: MAX is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation.The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Multiple alternatively spliced transcript variants have been described for this gene but the full length nature for some of them is unknown.
Alias Symbols: orf1, bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8
Protein Interaction Partner: USP37, UNC45A, BANP, FBXW11, MXI1, RPL35, TUBA1A, RPL34, GABBR1, FUS, FTH1, MYC, MXD1, MGA, PLIN3, HSP90AA1, TCF3, MYCN, CPSF6, ARL6IP5, KMT2D, HNRNPH2, DYNC1H1, CSTF2, SNIP1, PPP1CC, PPP1CB, PPP1CA, USF1, PCGF6, EP400, DMAP1, WDR5, BRD8, KAT5, MNT, MAX,
Protein Size: 160

Molecular Weight: 18 kDa

Gene ID: 4149

NCBI Accession: NM_002382, NP_002373

UniProt: P61244

Pathways: Mitotic G1-G1/S Phases