IRF4 antibody (Middle Region)

Catalog No. ABIN2780429

Product Details anti-IRF4 Antibody

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TAHVEPLLAR QLYYFAQQNS GHFLRGYDLP EHISNPEDYH RSIRHSSIQE

Predicted Reactivity: Dog: 100%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against IRF4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IRF4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 451 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-IRF4 antibody (ABIN2780429)

Han, Kraft, Nan, Guo, Chen, Qureshi, Hankinson, Hu, Duffy, Zhao, Martin, Montgomery, Hayward, Thomas, Hoover, Chanock, Hunter: "A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation." in: PLoS genetics, Vol. 4, Issue 5, pp. e1000074, (2008) (PubMed).

Target Details for IRF4

Target: IRF4 (Interferon Regulatory Factor 4 (IRF4))

Alternative Name: IRF4 (IRF4 Products)

Synonyms: LSIRF antibody, MUM1 antibody, NF-EM5 antibody, AI385587 antibody, IRF-4 antibody, Spip antibody, IRF4 antibody, si:ch73-170d1.2 antibody, irf4 antibody, interferon regulatory factor 4 antibody, interferon regulatory factor 4a antibody, Interferon regulatory factor 4 antibody, PWWP domain-containing protein MUM1 antibody, IRF4 antibody, Irf4 antibody, irf4a antibody, irf4 antibody, LOC612320 antibody, LOC100068881 antibody

Background: IRF4 is a transcriptional activator. It binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter.It also binds the immunoglobulin lambda light chain enhancer, together with PU.1. IRF4 probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.
Alias Symbols: LSIRF, MUM1, NF-EM5
Protein Interaction Partner: UBC, STAT6, BCL6, TOP1, IRAK1, PRRC2B, YTHDC2, VPS35, PEG10, TLK2, CARM1, IKBKAP, ETV7, BATF, HOXB13, PROX1, HOXC11, FKBP4, SPIB, PRDM1, MYD88, TRAF2, NFATC2, SPI1,
Protein Size: 451

Molecular Weight: 52 kDa

Gene ID: 3662

NCBI Accession: NM_002460, NP_002451

UniProt: Q15306

Pathways: Chromatin Binding