RFX1 antibody (N-Term)

Catalog No. ABIN2780453

This anti-RFX1 antibody is a Rabbit Polyclonal antibody detecting RFX1 in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Horse and Rabbit.

Quick Overview for RFX1 antibody (N-Term) (ABIN2780453)

Target: RFX1 (Regulatory Factor X, 1 (Influences HLA Class II Expression) (RFX1))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RFX1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RFX1 Antibody

Binding Specificity: N-Term

Sequence: PQPPQPPTAA ATPQPQYVTE LQSPQPQAQP PGGQKQYVTE LPAVPAPSQP

Predicted Reactivity: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against RFX1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RFX1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 979 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RFX1

Target: RFX1 (Regulatory Factor X, 1 (Influences HLA Class II Expression) (RFX1))

Alternative Name: RFX1

Background: This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. RFX1 is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: EF-C, EFC, RFX
Protein Interaction Partner: SOX2, SMAD9, SMAD4, SMAD1, NOTCH1, Cebpb, NCOA3, HDAC1, NFIC, NFIB, TADA3, RFX3, MAGED1, ABL1, NFIX, HMGB1, HIVEP2, RFX2, ADD1,
Protein Size: 979

Molecular Weight: 105 kDa

Gene ID: 5989

NCBI Accession: NM_002918, NP_002909

UniProt: P22670

Pathways: Human Leukocyte Antigen (HLA) in Adaptive Immune Response