PHOX2A antibody (C-Term)

Catalog No. ABIN2780651

Product Details anti-PHOX2A Antibody

Target: PHOX2A (Paired-Like Homeobox 2a (PHOX2A))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHOX2A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: VAGGGGGGPG AGAAELLKAW QPAESGPGPF SGVLSSFHRK PGPALKTNLF

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against PHOX2A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PHOX2A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 284 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PHOX2A

Target: PHOX2A (Paired-Like Homeobox 2a (PHOX2A))

Alternative Name: PHOX2A (PHOX2A Products)

Background: PHOX2A contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. PHOX2A has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene.
Alias Symbols: ARIX, CFEOM2, FEOM2, MGC52227, NCAM2, PMX2A
Protein Interaction Partner: SP1, PHOX2A, HAND2, PRKACA, ATF6B, CREBBP, JUN,
Protein Size: 284

Molecular Weight: 30 kDa

Gene ID: 401

NCBI Accession: NM_005169, NP_005160

UniProt: O14813